List of Previous Teleseminars

Previous DRSG Seminars – 2000-2017


Differences Between Scientific, Legal, and Public Policy Uses of Probability
Nathan Schachtman, Esq., (SRA Risk Policy and Law Specialty Group)
7 August 2018


The NTP Proposed Approach to Genomic Dose-Response Modeling
Scott Auerbach, National Toxicology Program (NTP)
7 August 2018


New Data for Dose Response, Specifically Using Toxcast Data
Richard Judson, U.S. Environmental Protection Agency
3 April 2018


Machine Learning in Dose-Response Assessment: Translating Science to Decisions (Abstract)
Jacqueline MacDonald Gibson, University of North Carolina at Chapel Hill
6 March 2018


Considerations for the Dose‐Response Analyses of Inorganic Arsenic Health Outcomes
Jeff Gift, U.S. EPA
3 October 2017
Recordings: Recording (49 MB); Audio Only (22 MB).


Understanding the Biochemical Origin of Sigmoidal Dose Responses: Ultrasensitive Response Motifs
Qiang Zhang, Emory University
5 September 2017
Recordings: Recording (80 MB); Audio Only (27 MB).


Using 21st Century Science for Risk-related evaluations: An Overview of the NAS Risk21 Report
Jonathan Samet, George Daston, & Lauren Zeise, On behalf of the National Academies Risk21 Committee
1 August 2017


Exposure‐Response in Environmental Toxicology and Risk Assessment, from Receptors to Ecological Landscapes
Wayne G. Landis, Western Washington University
2 May 2017


Health and Economic Consequences of Endocrine Disruptors in the US and EU
Leo Transande, New York University
4 April 2017


Facilitated Discussion: Mentoring in Risk Assessmenr
2 February 2017


Strengthening human health risk assessment of chemicals by integration of toxicogenomics data
Julie Bourdon-Lacombe,, Health Canada
4 October 2016


Bayesian dose-response analysis for re-assessment of arsenic-tumor data
Lyle D. Burgoon, U.S. Army Engineer Research and Development Center
6 September 2016


Statistical strategy for determining sufficient similarity of complex mixtures: A case study of ginkgo biloba extract
Chris Gennings, Icahn School of Medicine at Mount Sinai
2 August 2016


Potency of opportunistic pathogens in water systems
Jade Mitchell, Michigan State University
5 July 2016


Complete protection against aflatoxin B1-induced liver cancer with a triterpenoid: DNA adduct dosimetry and genotoxicity threshold
Bill D. Roebuck, The Geisel School of Medicine at Dartmouth
5 April 2016


Modeling U-shaped exposure-response relationships for agents that demonstrate toxicity due to both excess and deficiency
Daniel Krewski, University of Ottawa
6 October 2015


Perinatal stress and early childhood respiratory disorders: dose-response and sex-specific effects
Rosalind Wright, Mount Sinai Hospital
1 September 2015


What would Willie Sutton say about dose response analysis for unconventional gas drilling?
Bernard Goldstein, (Emeritus) University of Pittsburgh Schools of the Health Sciences
7 July 2015


Risk Analysis – Visions for the Future
Dale Hattis, Clark University
2 June 2015


The Interaction Between Chemical and Physical Agents: The Example of Ototoxicants and Noise
Thais C. Morata, NIOSH National Occupational Research Agenda Manufacturing Sector Council
7 October 2014


Application of the WHO Framework for Combined Exposures: Implications for Assessment
Bette Meek, Institute of Population Health, University of Ottawa
2 September 2014


NCTR/FDA Research on BPA: Integrating Pharmacokinetics in Animal Models and Humans, Rat Toxicology Studies, Human Biomonitoring, and PBPK Modeling into Risk Assessment
Daniel Doerge, National Center for Toxicological Research, FDA
5 August 2014


Mixtures Research at the National Institute of Environmental Health Sciences (NIEHS)
Cynthia Rider, National Toxicology Program, NIEHS
6 May 2014


U.S. EPA State of the Science Evaluation: Nonmonotonic Dose Responses as They Apply to Estrogen, Androgen, and Thyroid Pathways and EPA Testing and Assessment Procedures
Rita Schoeny, USEPA Office of Science Policy
1 October 2013


The Non-Linear Nasal Carcinogen Vinyl Acetate and Some Challenges of Tox21 for Non-Linear Dose-Response Assessment
Justin Teeguarden, Pacific Northwest National Laboratory
10 September 2013


Model Averaged Benchmark Dose Estimations—From Research to Practice
Kan Shao, USEPA National Center for Environmental Assessment
6 August 2013


State-of-the-Science: Inhalation Gas Dosimetry and Risk Assessment
John Stanek, USEPA National Center for Environmental Assessment
2 April 2013


Improving Risk Assessment for Mixtures Using Dose-Dependent Responses
Resha Putzrath, Navy and Marine Corps Public Health Center
4 September 2012


Evaluating the Plausibility of Estrogen Receptors as Mediators of BPA Toxicity in the Context of Human Serum Concentrations of Unconjugated BPA
Justin Teeguarden, Pacific Northwest National Laboratory
4 June 2012


Bisphenol A: Evaluating Toxicity and Dose Response in Rodent Models
Barry Delclos, U.S. FDA
3 April 2012


Computational Toxicology and High-Throughput Risk Assessment
Richard Judson, U.S. EPA
6 September 2011


Integration of Dosimetry, Human Exposure and High-Throughput Screening Data in the Toxicity Assessment of Environmental Chemicals
Barbara Wetmore, Hamner Institutes for Health Sciences
June 7, 2011


NexGen Risk Assessments: Challenges and Opportunities for Dose-Response Assessment
Weihsueh Chiu, U.S. EPA
12 April 2011


The Use and Misuse of Dose Thresholds in Risk Assessment
Kenny Crump, Louisiana Tech University
7 September 2010


Microbial Dose-Response & Its Use in Estimating the Benefits of EPA’s Drinking Water Rules
Jeff Swartout, U.S. EPA National Center for Environmental Assessment
Mike Messner, U.S. EPA Office of Ground Water and Drinking Water
Stig Regli, U.S. EPA Office of Ground Water and Drinking Water
3 August 2010


Threshold of Toxicological Concern (TTC)
Michael Laufersweiler, Procter & Gamble Central Product Safety, and
Stephen Olin, ILSI Research Foundation
3 March 2010


High Throughput Screening for Hazard and Risk of Environmental Contaminants
David J. Dix, U.S. EPA
6 October 2009


Using Empirical Data on Toxicity Pathways in the Prediction of Responses at Low Doses
Paul Price, Dow Chemical Company
1 September 2009


Chemical-Specific Adjustment Factors: The IPCS Approach to Developing Non-Default Values for Inter and Intra-species Extrapolation
John Lipscomb, U.S. EPA
Categorical Regression Modeling of Multiple Effects from Chemical Mixture Exposures in Cumulative Risk Assessment
Linda Teuschler, U.S. EPA
9 June 2009


Discussion of National Academy of Sciences Report - Science and Decisions: Advancing Risk Assessment
Michael Dourson, TERA
3 March 2009


The BMD Approach in Europe: Recent Developments in Acceptance, and Some Specific Views
Wout Slob, RIVM
2 September 2008


Dose-Response Analysis in Environmental Risk Assessment:
Where Are We, and Where Are We Going?
Weihsueh Chiu, U.S. EPA
3 June 2008


Characterizing Dose-Response Model Uncertainty Using Model Averaging
Matthew Wheeler, NIOSH
5 March 2008


Radiation Cancer Risk Estimates and the Use of the Linear Nonthreshold Model
Julian Preston, U.S. EPA
11 September 2007


Toxicokinetics and Risk Assessment, a text
John Lipscomb, U.S. EPA
5 June 2007


PBPK Modeling for Acrylamide: Relating Mechanisms, Adducts, Metabolites, and Kinetics to Risk Assessment
Daniel R. Doerge; John F. Young, NCTR, U.S. FDA
6 March 2007


Intraspecies Variability in Toxicant Effects: Nuisance, Nemesis or Sustenance for Risk Assessment?
Robert MacPhail, U.S. EPA
5 September 2006


Mode of Action in Assessing the Human Relevance of Animal Tumors: An EPA Perspective
Vicki Dellarco; Anna Lowit, U.S. EPA
6 February 2006


Inhalation Toxicity of Single Wall Carbon Nanotubes
Robert R. Mercer, NIOSH Unique Properties of Nanomaterials that Raise Concerns for Toxicology Research
Jo Anne Shatkin, The Cadmus Group
6 June 2006


Computational Systems Biology and Dose Response Assessment
Mel Andersen, CIIT Centers for Health Research
6 September 2005


Age-Related Differences in Susceptibility to Carcinogenesis—Human Risk Inferences from an Analysis of Animal Bioassay Data
Dale Hattis, Clark University
7 June 2005


Update on International Initiatives for Chemical Specific Adjustment Factors and Physiologically Based Pharmacokinetic (PBPK) Models for Use in Risk Assessment
Bette Meek, Health Canada
1 March 2005


Benchmark-Dose Shopping with Proper Confidence
Walter Piegorsch, University of South Carolina
7 September 2004


Dose-Dependent Transitions in Toxic Mechanisms: Implications for Risk Assessment
David Gaylor, Gaylor and Associates
1 June 2004


Arsenic: Proposed Mechanisms and Risk Assessment Implications
Michael Luster, NIOSH
2 March 2004


Cumulative Risk Assessment for Chemical Mixtures
James Chen, U.S. National Center for Toxicological Research
2 September 2003


Dose-Response Curves in Chemical Carcinogenesis
William Waddell, University of Louisville
3 June 2003


Bystanders, Adaptive Responses and Genomic Instability – Potential Modifiers of Low-Dose Cancer Responses
Julian Preston, U.S. EPA
4 March 2003


Model Uncertainty in Microbial Risk Assessment
Ravi Varadhan, Johns Hopkins University
3 September 2002


Computational Modeling of Mechanisms of Nonmonotonic Dose-Response: Androgen Receptor Activation and Tumor Incidence
Rory Conolly, CIIT Centers for Health Research
4 June 2002


Variability in Dose-Response Assessments
Wout Slob, RIVM
5 March 2002


Dioxin: Dose-Response for Acute Effects
Jim Wilson, Resources for the Future
4 September 2001


Assessment of Risks to Children from Exposure to Environmental Agents
Gary Kimmel, U.S. EPA
Chemical Mixtures Risk Assessment: Current Approaches and Emerging Issues
Peter Robinson, ManTech
Integrating Toxicokinetics and Toxicodynamics in Mechanistic Risk Assessment
Jeff Swartout, U.S. EPA
Risks from Various Exposure Durations
Ron Brown, FDA
4 June 2001


Compound Specific Adjustment Factors – An International Perspective
Bette Meek, Health Canada
3 April 2001


A Model for the Development of Tolerable Upper Intake Levels for Nutrients
Elizabeth Reese; Joseph Rodricks, The Life Science Consultancy
Steve Taylor, University of Nebraska
3 October 2000


Microbial Dose-Response Modeling: Surrogate Dose-Response Models for the Foodborne Pathogen E. coli O157:H7
Peg Coleman, USDA
6 June 2000